Pharmacokinetic/Pharmacodynamic and Toxicokinetic Services

ChemPartner has in-depth DMPK knowledge and experiences to deliver high quality DMPK services. The following are types of DMPK services that can be provided with fast turnaround time at competitive prices:

Pharmacokinetic/Pharmacodynamic and Toxicokinetic Services

• Bioavailability study (po, sc, im, ip, etc.)
• Single dose and multiple dose PK study in mouse, rat, dog and monkey
• Cassette (N-in-one) PK for early discovery compound screening and ranking order
• Drug distribution in tissue/organ and body fluid (urine, bile, CSF, synovial fluid, etc) and determination of blood and brain concentration ratio
• PK study for pharmaceutical formulation development and form evaluation
• Short term TK for non-GLP exploratory safety evaluation
• PK/PD study for design of dose and dose regimen in rodent disease models of inflammation and cancer
• Special PK study, including evaluation of food, gender, co-medicine and gastric pH effects on PK, interspecies allometry scaling for first in human PK dose selection
• Design and execution of IND-enabling DMPK studies for regulatory submission with both small molecules and biologics